Distraction osteogenesis (DO), also called callus distraction, callotasis and osteodistraction, is a process used in orthopedic surgery, podiatric surgery, and oral and maxillofacial surgery to repair skeletal deformities and in reconstructive surgery. The procedure involves cutting and slowly separating bone, allowing the bone healing process to fill in the gap.
Distraction osteogenesis (DO) is used in orthopedic surgery, podiatric surgery, and oral and maxillofacial surgery to repair skeletal deformities and in reconstructive surgery. It was originally used to treat problems like unequal leg length, but since the 1980s is most commonly used to treat issues like hemifacial microsomia, micrognathism (chin so small it causes health problems), craniofrontonasal dysplasias, craniosynostosis, as well as airway obstruction in babies caused by glossoptosis (tongue recessed too far back in the mouth) or micrognathism.
In 2016 a systematic review of papers describing bone and soft tissue outcomes of DO procedures on the lower jawbone was published; the authors had planned to do a meta-analysis but found the studies were too poor in quality and too heterogeneous to pool. From what they were able to generalize, the authors found there was significant relapse in the vertical plane for bone, and a higher risk of relapse when there was an initial high gonial angle or Jarabak ratio (sella–gonion/nasion– menton). For soft tissue, little evidence was available regarding the vertical dimension, while a 90% correspondence between skeletal and soft tissue was found for sagittal positioning; the dentalto-soft tissue agreement was around 20%.
A 2016 Cochrane review of DO on the upper jawbone to treat cleft lip and cleft palate compared with orthognathic surgery found only one study, involving 47 participants and performed between 2002 and 2008 at the University of Hong Kong. This was not sufficient evidence from which to generalize, but the authors noted that while both procedures produced notable hard and soft tissue improvements, the DO group had greater advancement of the maxillary and less horizontal relapse five years after surgery. There was no difference in speech or nasal emissions outcomes nor in adverse effects; the DO group had lower satisfaction at three months after surgery but higher at two years.
In the first phase, called the "osteotomy/surgical phase", the bone is cut, either partially, only through the hard exterior, or completely, and a device is fitted which will be used in the next phases. In the second phase, the latency period, which lasts generally seven days, the appliance is not activated and early stages of bone healing are allowed. In the third phase, the "distraction phase", the device, which is mounted to the bone on each side of the cut, is used to gradually separate the two pieces, allowing new bone to form in the gap. When the desired or possible length is reached, which usually takes three to seven days, a consolidation phase follows in which the device keeps the bone stable to allow the bone to fully heal. After the consolidation phase, the device is removed in a second surgical procedure.
The device that is used is usually manually operated by twisting a rod that through a rack and pinion system or the like, separates the bone; the rate of separation is carefully determined because going too quickly can cause nonunion, in which unstable fibrous connective tissue is formed instead of bone, and going too slowly can allow premature union to occur. Generally, the rate is about a millimeter per day, achieved in two steps per day. The frequency of steps and how much the device is moved at each step, is called the "rhythm". The devices sometimes contain a spring that provides tension to continually separate the bones, instead of being manually operated at set intervals.
Despite these manually operated systems there are also motorized systems like the FITBONE from WITTENSTEIN. The FITBONE is a fully implantable, motorized, lengthening and correction nail. Advantages of this device are accurate deformity correction, low scar tissue formation, and reduced risk of infection. Furthermore, the patients describe the procedure as more comfortable than limb lengthening with mechanical systems.
Risks include infection (5% overall, with 1% of those requiring pin removal and the bone becoming infected in .5%), failure for bone to grow in the desired direction (between 7 and 9%), hardware failure (between 3 and 4.5%), failure to follow the distraction protocol (4.5% overall; too slow 2% and too fast .5%), 1% pain due to distraction ending the procedure; damage to the inferior alveolar nerve occurs in 3.5% of mandibular distraction, tooth bud injury in 2%, and facial nerve injury in 0.5% of cases.
The procedure was first proposed by Bernhard von Langenbeck in 1869, but the first publication of efforts to implement it clinically was by Alessandro Codivilla in 1905. The paper presented the results of efforts to treat 26 people who were born with malformed legs; Codivilla cut the femur, put a pin in the heel bone, and applied traction to each person. His paper showed high levels of complications, including infection, tissue death, and bones that failed to join, and his methods were not adopted.
The Russian orthopedic surgeon Gavriil Ilizarov studied DO methods in over 15,000 people starting in the 1950s; he developed external fixation devices and methods to separate severed leg bones gradually, and using them he determined optimal rates of separation. His work led to widespread use of DO. The first use in the jaw was pioneered by Wolfgang Rosenthal in 1930 but it was not further explored until the 1980s; the first paper of the modern era describing clinical use was published in 1992.
Society and culture
In China in the early 2000s after economic reform and especially following the privatization of many sectors of the economy, a fad for cosmetic surgery swept China, which included some people undergoing distraction osteogenesis solely to become taller; Chinese media often featured stories in which people ended up with weak bones or splayed feet as a result.
As of 2016 work was underway developing devices and techniques that would allow DO in more directions simultaneously. As of 2013 work was underway on distraction devices using Shape-memory alloy that could precisely separate bone without the need for intervention, as well as springs and motors; the use of biopharmaceuticals like BMP in combination with devices was also being explored.
1. Seaward J, Kane A (2013). "Distraction Osteogenesis". In Kountakis SE.
Encyclopedia of Otolaryngology, Head and Neck Surgery. Springer. pp. 700–710. ISBN 978-3-642-23499-6.
2. Baur DA, Helman J, Rodriguez JC, Altay MA (March 8, 2016). Meyers AD, ed.
"Distraction Osteogenesis of the Mandible”. Medscape Emedicine Drugs and Diseases. Retrieved 31 October 2016.
3. Patel PK, Zhao L, Ellis MF (January 6,
2015). de la Torre JI, ed. "Distraction
Osteogenesis: Background, History of the Procedure, Pathophysiology”. Medscape Emedicine: Drugs and Diseases.
4. Rossini G, Vinci B, Rizzo R, Pinho TM, Deregibus A (November 2016). "Mandibular distraction osteogenesis: a systematic review of stability and the effects on hard and soft tissues". International Journal of Oral and Maxillofacial Surgery. 45 (11):
doi: 10.1016/j.ijom.2016.08.012. PMID 27609710.
5. Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C (September 2016). "Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients". The Cochrane Database of Systematic Reviews. 9: CD010403.
doi: 10.1002/14651858.CD010403.pub2. PMID 27689965.
6. Baumgart R, Bürklein D, Hinterwimmer S, Thaller P, Mutschler W (July 2005). "The management of leg-length discrepancy in Ollier's disease with a fully implantable lengthening nail". The Journal of Bone and Joint Surgery. British Volume. 87 (7): 1000–
4. doi:10.1302/0301-620x.87b7.16365. PMID 15972921.
7. Küçükkaya M, Karakoyun Ö, Sökücü S, Soydan R (January 2015). "Femoral lengthening and deformity correction using the Fitbone motorized lengthening nail”.
Journal of Orthopaedic Science. 20 (1):
149–54. doi:10.1007/s00776-014-0659-3. PMC 4302230. PMID 25326815.
8. Baumgart R, Betz A, Schweiberer L (October 1997). "A fully implantable motorized intramedullary nail for limb lengthening and bone transport". Clinical Orthopaedics and Related Research (343): 135–43. PMID 9345218.
9. Accadbled F, Pailhé R, Cavaignac E, Sales de Gauzy J (April 2016). "Bone lengthening using the Fitbone (®) motorized intramedullary nail: The first experience in France". Orthopaedics & Traumatology, Surgery & Research. 102 (2): 217–22. doi: 10.1016/j.otsr.2015.10.011. PMID 26874445.
10. Codivilla A (1905). "On the means of lengthening in the lower limbs, the muscles, and tissues which are shortened through deformity". American Journal of
Orthopedics Surgery. 2: 353–69. Reprinted in Codivilla A (December 2008). "The classic: On the means of lengthening, in the lower limbs, the muscles and tissues which are shortened through deformity. 1905”. Clinical Orthopaedics and Related Research. 466 (12): 2903–9.
PMC 2628224. PMID 18820986.
11. McCarthy JG, Schreiber J, Karp N, Thorne CH, Grayson BH (January 1992). "Lengthening the human mandible by gradual distraction". Plastic and Reconstructive Surgery. 89 (1): 1–8, discussion 9-10. doi:10.1097/00006534199289010-00001. PMID 1727238.
12. Watts J (March 2004). "China's cosmetic surgery craze. Leg-lengthening operations to fight height predjudice can leave patients crippled". Lancet. 363 (9413):
958. doi:10.1016/s0140-6736(04)15832-7. PMID 15046120.
13. Gomi A, Sunaga A, Kamochi H, Oguma
H, Sugawara Y (May 2016). "Distraction Osteogenesis Update: Introduction of
Multidirectional Cranial Distraction
Osteogenesis”. Journal of Korean Neurosurgical Society. 59 (3): 233–41.
PMC 4877545. PMID 27226854.
14. Saman M, Abramowitz JM, Buchbinder D (May 2013). "Mandibular osteotomies and distraction osteogenesis: evolution and current advances". JAMA Facial Plastic Surgery. 15 (3): 167–73.